Maturation of human iPS cell-derived dopamine neuron precursors in alginate-Ca(2+) hydrogel.

@article{Komatsu2015MaturationOH,
  title={Maturation of human iPS cell-derived dopamine neuron precursors in alginate-Ca(2+) hydrogel.},
  author={Masaaki Komatsu and Shuhei Konagaya and Edgar Yuji Egawa and Hiroo Iwata},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1850 9},
  pages={
          1669-75
        }
}
BACKGROUND Pluripotent stem cells (embryonic stem/induced pluripotent stem cells) have been widely studied as a potential cell source for cell transplantation therapy of Parkinson's disease. However, some difficulties remain to be overcome. These include the need to prepare a large number of dopamine (DA) neurons for clinical use and to culture the cells for a long period to allow their functional maturation and the removal of undifferentiated cells. METHODS In this study, aggregates of DA… CONTINUE READING
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