Maturation of glucose-stimulated insulin secretion in fetal sheep.

@article{Aldoretta1998MaturationOG,
  title={Maturation of glucose-stimulated insulin secretion in fetal sheep.},
  author={Peter W. Aldoretta and Thomas D Carver and William W Jr Hay},
  journal={Biology of the neonate},
  year={1998},
  volume={73 6},
  pages={
          375-86
        }
}
To determine the gestational maturation of fetal insulin response to glucose and arginine and the effects of sustained hyperglycemia on these processes, we measured insulin secretion in different groups of fetal sheep at 75, 100, 122, and 137 days of gestation (50, 67, 81, and 91% of term gestation, respectively). The basal glucose concentration decreased progressively from 1.36 +/- 0.16 mM at 75 days to 1.00 +/- 0.07 mM at 137 days (p < 0.05). The fetal plasma insulin concentration did not… CONTINUE READING
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