Maturation of fatty acid and carbohydrate metabolism in the newborn heart

@article{Makinde1998MaturationOF,
  title={Maturation of fatty acid and carbohydrate metabolism in the newborn heart},
  author={A-Olufemi Makinde and Paul Fraser Kantor and Gary D Lopaschuk},
  journal={Molecular and Cellular Biochemistry},
  year={1998},
  volume={188},
  pages={49-56}
}
During fetal life, myocardial ATP is derived predominantly from glycolysis and lactate oxidation. Following birth, a rapid maturational increase in fatty acid oxidation occurs along with a decline in glycolytic and lactate oxidative rates, thus changing the major source of myocardial ATP production. This shift in energy substrate preference occurs in response to changes in the circulating substrate content of newborn plasma with the onset of suckling, and is also due to alterations in… CONTINUE READING
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