Maturation of eukaryotic ribosomes: acquisition of functionality.

  title={Maturation of eukaryotic ribosomes: acquisition of functionality.},
  author={Vikram Govind Panse and Arlen W Johnson},
  journal={Trends in biochemical sciences},
  volume={35 5},
In eukaryotic cells, ribosomes are pre-assembled in the nucleus and exported to the cytoplasm where they undergo final maturation. This involves the release of trans-acting shuttling factors, transport factors, incorporation of the remaining ribosomal proteins, and final rRNA processing steps. Recent work, particularly on the large (60S) ribosomal subunit, has confirmed that the 60S subunit is exported from the nucleus in a functionally inactive state. Its arrival in the cytoplasm triggers… CONTINUE READING

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