Maturation of embryonic stem cells into endothelial cells in an in vitro model of vasculogenesis.

@article{Hirashima1999MaturationOE,
  title={Maturation of embryonic stem cells into endothelial cells in an in vitro model of vasculogenesis.},
  author={Masanori Hirashima and Hiroshi Kataoka and Norihisa Matsuyoshi and Satomi Nishikawa},
  journal={Blood},
  year={1999},
  volume={93 4},
  pages={1253-63}
}
A primitive vascular plexus is formed through coordinated regulation of differentiation, proliferation, migration, and cell-cell adhesion of endothelial cell (EC) progenitors. In this study, a culture system was devised to investigate the behavior of purified EC progenitors in vitro. Because Flk-1(+) cells derived from ES cells did not initially express other EC markers, they were sorted and used as EC progenitors. Their in vitro differentiation into ECs, via vascular endothelial-cadherin (VE… CONTINUE READING

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