Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens.

Abstract

LEAPS (ligand epitope antigen presentation system) vaccines consist of a peptide containing a major histocompatibility antigen binding peptide conjugated to an immune cell binding ligand (ICBL) such as the 'J' peptide from beta-2-microglobulin. Treatment of monocytes, monocytes plus GMCSF, or monocytes plus GMCSF and IL4 with JgD (containing a peptide from gD of herpes simplex virus type 1) or JH (with a peptide from HIV p17 gag protein) was sufficient to promote their maturation into Interleukin 12 producing dendritic cells. JgD-dendritic cells supported allotypic activation of T cells to produce Th1-related cytokines.

DOI: 10.1016/j.cellimm.2010.01.003

Cite this paper

@article{Taylor2010MaturationOD, title={Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens.}, author={Patricia R. Taylor and Christopher C. Paustian and Gary K. Koski and Daniel Zimmerman and Ken S Rosenthal}, journal={Cellular immunology}, year={2010}, volume={262 1}, pages={1-5} }