Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism.

@article{Thomas2003MaturationOD,
  title={Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism.},
  author={Paul G. Thomas and Michele R. Carter and Olga Atochina and Akram A. Da'dara and Danuta Piskorska and E J Mcguire and Donald A. Harn},
  journal={Journal of immunology},
  year={2003},
  volume={171 11},
  pages={5837-41}
}
The biology of pathogen-associated molecular patterns (PAMPs) stimulating APCs to differentiate into a Th1-promoting phenotype has been well characterized. Conversely, not a single pathogen product that promotes a Th2 phenotype has been rigorously identified. Strong Th2 responses and dendritic cell 2 maturation are driven by helminth extracts, and carbohydrates have been shown to be responsible for much of this activity. In this study, we show that a helminth carbohydrate, lacto-N-fucopentaose… CONTINUE READING
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