Maturation of Xenopus laevis oocyte by progesterone requires poly(A) tail elongation of mRNA.

@article{Kuge1992MaturationOX,
  title={Maturation of Xenopus laevis oocyte by progesterone requires poly(A) tail elongation of mRNA.},
  author={H Kuge and Akira Inoue},
  journal={Experimental cell research},
  year={1992},
  volume={202 1},
  pages={52-8}
}
Meiotic maturation of Xenopus laevis oocytes by progesterone requires translation of stored maternal mRNAs. We investigated the role of poly(A) tail elongation of mRNAs during this process using cordycepin, which inhibits poly(A) tail elongation of mRNAs. When oocytes were treated with the buffer containing 10 mM cordycepin for 12 h, concentration of 3'-dATP in cytosol of oocytes increased to 0.7 mM, while that of ATP remained constant at around 1.2 mM. Incorporation of [32P]AMP into poly(A… CONTINUE READING

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