Maturation of CD4+ lymphocytes in the aged microenvironment results in a memory-enriched population.

@article{Timm1999MaturationOC,
  title={Maturation of CD4+ lymphocytes in the aged microenvironment results in a memory-enriched population.},
  author={Jenna A. Timm and Marilyn L. Thoman},
  journal={Journal of immunology},
  year={1999},
  volume={162 2},
  pages={711-7}
}
With advancing age the CD4+ T lymphocyte compartment becomes enriched for memory cells in both humans and experimental animals. Although it has been assumed that the shift from a naive to a memory-dominant population is due to a lifetime of antigenic exposure and selection as well as a loss of naive cell input due to reduced thymopoiesis, the present data suggest that the aged microenvironment influences the maturation of newly produced CD4+ T cells. In two models, aged and young mice were… CONTINUE READING

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