Maturation of "neocortex isole" in vivo in mice.

  title={Maturation of "neocortex isole" in vivo in mice.},
  author={Libing Zhou and David Gall and Yibo Qu and Cynthia Prigogine and Guy Cheron and Fadel Tissir and Serge N Schiffmann and Andre M Goffinet},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={30 23},
How much neocortical development depends on connections remains elusive. Here, we show that Celsr3|Dlx mutant mice have no extrinsic neocortical connections yet survive to postnatal day 20, acquire a basic behavioral repertoire, and display spontaneous hyperactivity, with abnormal light/dark activity cycling. Except for hallmarks related to thalamic input, such as barrels in somatosensory cortex, cortical arealization and laminar maturation proceeded normally. However, the tangential extension… CONTINUE READING


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