Maturation-dependent sensitivity of oligodendrocyte lineage cells to apoptosis: implications for normal development and disease

@article{Butts2008MaturationdependentSO,
  title={Maturation-dependent sensitivity of oligodendrocyte lineage cells to apoptosis: implications for normal development and disease},
  author={Brent D. Butts and Caroline Houde and Huseyin Mehmet},
  journal={Cell Death and Differentiation},
  year={2008},
  volume={15},
  pages={1178-1186}
}
Apoptosis plays a crucial role in brain development by ensuring that only appropriately growing, migrating, and synapse-forming neurons and their associated glial cells survive. This process involves an intimate relationship between cell–cell interactions and developmental cues and is further impacted by environmental stress during neurogenesis and disease. Oligodendrocytes (OLs), the major myelin-forming cells in the central nervous system, largely form after this wave of neurogenesis but also… CONTINUE READING

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