Maturation-dependent repair of untreated osteochondral defects in the rabbit knee joint.

Repair of untreated full-thickness cartilage defects in the medial femoral knee condyle was studied in 17 young, 21 adolescent, and 19 adult rabbits. At 6 weeks, the defect was completely filled by tissue regeneration in all young and adolescent animals, but in only few of the adults (p < 0.05). The morphology of all repairs improved from fibrous tissue to… (More)