Maturation-dependent microstructure length scale in the corpus callosum of fixed rat brains by magnetic resonance diffusion-diffraction.

@article{Weng2007MaturationdependentML,
  title={Maturation-dependent microstructure length scale in the corpus callosum of fixed rat brains by magnetic resonance diffusion-diffraction.},
  author={Jun-Cheng Weng and Jyh-Horng Chen and Li-Wei Kuo and Van J. Wedeen and Wen-Yih Isaac Tseng},
  journal={Magnetic resonance imaging},
  year={2007},
  volume={25 1},
  pages={
          78-86
        }
}

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References

SHOWING 1-10 OF 21 REFERENCES
Assessment of axonal fiber tract architecture in excised rat spinal cord by localized NMR q‐space imaging: Simulations and experimental studies
TLDR
The data suggest the NMR q‐space approach has potential for nondestructive analysis of the axonal architecture in the mammalian spinal cord, and mean displacements and kurtosis parallel mean axon size and axonal density are calculated.
Water diffusion, T2, and compartmentation in frog sciatic nerve
A potential relationship between structural compartments in neural tissue and NMR parameters may increase the specificity of MRI in diagnosing diseases. Nevertheless, our understanding of MR of
Localized q‐space imaging of the mouse brain
TLDR
Localized q‐space imaging was used to obtain water displacement profiles from mouse brain that take the form of unidirectional diffusive displacement probability distributions, consistent with the diffusion‐weighted image intensity changes that occur after a period of ischemia.
Displacement imaging of spinal cord using q‐space diffusion‐weighted MRI
TLDR
It was found that changes in the diffusion characteristics of white matter upon maturation are responsible for the emergence of gray/white matter contrast and this new imaging methodology was used to follow spinal cord maturation in the rat.
Principles of Nuclear Magnetic Resonance Microscopy
now a well-established method of whole-body scanning in medicine. On the other hand. NMRI can also be applied at small scale and then at relatively high spatial resolution to small animals, natural
Assignment of coherence features in NMR q-space plots to particular diffusion modes in erythrocyte suspensions.
TLDR
Random walk simulations using a Monte Carlo procedure helped verify the interpretations of the assignment of the features of the plots to molecules diffusing in the two regions and revealed how the presence or absence of transmembrane exchange affects the form of q-space plots.
NMR “diffusion‐diffraction” of water revealing alignment of erythrocytes in a magnetic field and their dimensions and membrane transport characteristics
TLDR
The relevance of these findings to NMR‐based histological characterization of tissues, and the implications, for magnetic resonance imaging (MRI), of eryth‐rocyte alignment in the small vessels of the brain in particular, are noted.
...
...