Maturation but not survival of dopaminergic nigrostriatal neurons is affected in developing and aging BDNF-deficient mice.

Abstract

Brain-derived neurotrophic factor (BDNF) promotes survival of injured dopaminergic nigrostriatal neurons of the adult rodent substantia nigra pars compacta, as well their development in vitro. BDNF deficiency may play a role in Parkinson's disease, as the surviving dopaminergic nigrostriatal neurons have reduced levels of BDNF, and a BDNF gene polymorphism… (More)

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@article{Baker2005MaturationBN, title={Maturation but not survival of dopaminergic nigrostriatal neurons is affected in developing and aging BDNF-deficient mice.}, author={Sarah A Baker and Lianne E Stanford and Richard E. Brown and Theo Hagg}, journal={Brain research}, year={2005}, volume={1039 1-2}, pages={177-88} }