Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

@article{Bruin2013MaturationAF,
  title={Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice},
  author={Jennifer E. Bruin and Alireza Rezania and John Xu and K. J. Werle Narayan and Jessica K. Fox and John J. O’Neil and Timothy J Kieffer},
  journal={Diabetologia},
  year={2013},
  volume={56},
  pages={1987-1998}
}
Aims/hypothesisIslet transplantation is a promising cell therapy for patients with diabetes, but it is currently limited by the reliance upon cadaveric donor tissue. We previously demonstrated that human embryonic stem cell (hESC)-derived pancreatic progenitor cells matured under the kidney capsule in a mouse model of diabetes into glucose-responsive insulin-secreting cells capable of reversing diabetes. However, the formation of cells resembling bone and cartilage was a major limitation of… CONTINUE READING
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