Maturation and function of human dendritic cells are regulated by B lymphocytes.

@article{Morva2012MaturationAF,
  title={Maturation and function of human dendritic cells are regulated by B lymphocytes.},
  author={Ahsen Morva and S{\'e}bastien Lemoine and Achouak Achour and Jacques-Olivier Pers and Pierre Y. Youinou and Christophe Jamin},
  journal={Blood},
  year={2012},
  volume={119 1},
  pages={
          106-14
        }
}
Mature dendritic cells (DCs) are stimulators of T-cell immune response, whereas immature DCs support T-cell tolerance. Murine B cells can inhibit the production of IL-12 by DCs and thereby hinder the inflammatory response. Notwithstanding the importance of this modulation, only a few studies are available in humans. Here, we have developed an in vitro model of cocultures to assess its significance. We establish that human activated B cells restrained the development of monocytes into immature… 
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