Maturation-Dependent HIV-1 Surface Protein Redistribution Revealed by Fluorescence Nanoscopy

@article{Chojnacki2012MaturationDependentHS,
  title={Maturation-Dependent HIV-1 Surface Protein Redistribution Revealed by Fluorescence Nanoscopy},
  author={Jakub Chojnacki and Thorsten M. Staudt and B{\"a}rbel Glass and Pit Bingen and Johann Engelhardt and Maria Anders and Jale Schneider and Barbara M{\"u}ller and Stefan W. Hell and Hans‐Georg Kr{\"a}usslich},
  journal={Science},
  year={2012},
  volume={338},
  pages={524 - 528}
}
Switching on HIV Newly assembled human immunodeficiency virus (HIV) virions bud from the host cell as immature particles. Proteolysis of the Gag protein, which forms a structural lattice below the viral membrane, leads to the formation of mature infectious HIV. Fusion of mature HIV virions with a target cell is mediated by viral envelope (Env) proteins that occur in trimeric “spikes” on the surface of the virion. Chojnacki et al. (p. 524) used subdiffraction microscopy to show that the spikes… 

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...

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