Matthews coefficient probabilities: Improved estimates for unit cell contents of proteins, DNA, and protein-nucleic acid complex crystals.

@article{Kantardjieff2003MatthewsCP,
  title={Matthews coefficient probabilities: Improved estimates for unit cell contents of proteins, DNA, and protein-nucleic acid complex crystals.},
  author={Katherine A. Kantardjieff and Bernhard Rupp},
  journal={Protein science : a publication of the Protein Society},
  year={2003},
  volume={12 9},
  pages={1865-71}
}
Estimating the number of molecules in the crystallographic asymmetric unit is one of the first steps in a macromolecular structure determination. Based on a survey of 15641 crystallographic Protein Data Bank (PDB) entries the distribution of V(M), the crystal volume per unit of protein molecular weight, known as Matthews coefficient, has been reanalyzed. The range of values and frequencies has changed in the 30 years since Matthews first analysis of protein crystal solvent content. In the… CONTINUE READING
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X-ray crystallography at subatomic resolution

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