Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

@inproceedings{Leight2012MatrixRR,
  title={Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition},
  author={Jennifer L. Leight and Michele A. Wozniak and Sophia Chen and Michelle L. Lynch and Christopher S. Chen},
  booktitle={Molecular biology of the cell},
  year={2012}
}
The transforming growth factor-β (TGF-β) signaling pathway is often misregulated during cancer progression. In early stages of tumorigenesis, TGF-β acts as a tumor suppressor by inhibiting proliferation and inducing apoptosis. However, as the disease progresses, TGF-β switches to promote tumorigenic cell functions, such as epithelial-mesenchymal transition (EMT) and increased cell motility. Dramatic changes in the cellular microenvironment are also correlated with tumor progression, including… CONTINUE READING
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