Matrix revolutions: "tails" of basement-membrane components with angiostatic functions.

  title={Matrix revolutions: "tails" of basement-membrane components with angiostatic functions.},
  author={Gregory Bix and Renato V Iozzo},
  journal={Trends in cell biology},
  volume={15 1},
Angiogenesis, the creation of neovasculature from native blood vessels, is a prerequisite for many physiological and pathological processes. Recently, C-terminal tail fragments of several basement-membrane proteins such as endostatin, tumstatin and endorepellin have been shown to inhibit angiogenesis. Although there seems to be little or no homology among them, a common theme is that these fragments modulate endothelial cells by distinct interactions with integrins and activate distinct… CONTINUE READING
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