Matrix proteoglycans: from molecular design to cellular function.

  title={Matrix proteoglycans: from molecular design to cellular function.},
  author={Renato V. Iozzo},
  journal={Annual review of biochemistry},
  • R. Iozzo
  • Published 1 June 1998
  • Biology
  • Annual review of biochemistry
The proteoglycan superfamily now contains more than 30 full-time molecules that fulfill a variety of biological functions. Proteoglycans act as tissue organizers, influence cell growth and the maturation of specialized tissues, play a role as biological filters and modulate growth-factor activities, regulate collagen fibrillogenesis and skin tensile strength, affect tumor cell growth and invasion, and influence corneal transparency and neurite outgrowth. Additional roles, derived from studies… 

Figures and Tables from this paper

Proteoglycans: from structural compounds to signaling molecules

This review aims to summarize the multiple functions of proteoglycans with special emphasis on their intricate composition and the newly described signaling events in which these molecules play a key role.

Proteoglycans as Mediators of Cancer Tissue Mechanics

The significance of proteoglycans for therapy response, and the current experimental strategies that target proteoglyCans to sensitize cancer cells to treatment are discussed.

The Biology of the Small Leucine-rich Proteoglycans

  • R. Iozzo
  • Biology
    The Journal of Biological Chemistry
  • 1999
The focus is on the “functional network” created by these molecules in tissues, on genetic evidence for their functional roles during ontogeny, and on their activities as modulators of complex pathological processes such as fibrosis and cancer growth.

Proteoglycans of the extracellular matrix and growth control

It is emphasized that the modulatory role of proteoglycans on cell proliferation cannot be separated from their participation in tissue organization in general, thereby explaining the diverse and sometimes contradictory reports on the effects of proteglycans in cell proliferation and differentiation.

Transcriptional and posttranscriptional regulation of proteoglycan gene expression.

Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.

The primary goal of this comprehensive review is to summarize major achievements and paradigm-shifting discoveries made on the PG/GAG chemistry-biology axis, focusing on structural variability, structure-function relationships, metabolic, molecular, and epigenetic mechanisms underlying their synthesis.

Proteoglycans in prostate cancer

Emerging studies suggest that cancers, including those of the prostate, use changes in proteoglycan composition and structure to promote their own survival, growth, and spread.

Circular proteoglycans from sponges: first members of the spongican family

Sponge proteoglycans, for which the term spongicans is proposed, participate in signal transduction processes and are suspected to play a role in sponge self-nonself recognition.

Developmental roles of heparan sulfate proteoglycans: a comparative review in Drosophila, mouse and human.

Current evidence shows that at the very least, heparan sulfate proteoglycans need to be counted as legitimate elements of morphogenetic pathways that have been maintained throughout evolution as determinant mechanisms of pattern formation.

The family of the small leucine-rich proteoglycans: key regulators of matrix assembly and cellular growth.

  • R. Iozzo
  • Biology
    Critical reviews in biochemistry and molecular biology
  • 1997
These proteoglycans are tissue organizers, orienting and ordering collagen fibrils during ontogeny and in pathological processes such as wound healing, tissue repair, and tumor stroma formation, and three-dimensional modeling of their prototype protein core proposes a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.

Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function

  • R. IozzoA. Murdoch
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1996
This review focuses on the extracellular proteoglycans. Special emphasis is placed on the structural features of their protein cores, their gene organization, and their transcriptional control. A

Heparan sulfate proteoglycans of the cardiovascular system. Specific structures emerge but how is synthesis regulated?

The current state of knowledge about the structure and the biosynthesis of HSPGs are outlined as well as interactions of these components with growth factors, enzymes, and protease inhibitors are described to provide a conceptual framework for elucidating the roles of H SPGs in other biologic systems.

Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation

Chinese hamster ovary cell lines expressing human decorin from a stably transfected complementary DNA construct form a more orderly monolayer and grow to a lower saturation density than control cells lacking decorin, revealing a novel growth inhibitory mechanism which may be related to contact inhibition of cell proliferation.

Cartilage proteoglycans: Structure and potential functions

The largest in size and most abundant by weight is aggrecan, a proteoglycan that possesses over 100 chondroitin sulfate and keratan sulfate chains that provides cartilage with its osmotic properties, which give articular cartilage its ability to resist compressive loads.

Fibromodulin. A Perspective on Function.

Fibromodulin, the matrix glycoprotein discussed in this article, is found in many connective tissues where it appears to be primarily associated with fibrillar collagen, and it is suggested that this member of the group of small interstitial proteoglycans may serve additional functions beyond its proposed role in the modulation of collagen fibrillsogenesis.

A proteoglycan that activates fibroblast growth factors during early neuronal development is a perlecan variant.

It is concluded that PRM is a variant of perlecan that is differentially glycosylated in a manner that confers highly specific functions at critical stages of neural development and tissue growth.

Expression of Small Extracellular Chondroitin/Dermatan Sulfate Proteoglycans Is Differentially Regulated in Human Endothelial Cells*

The results indicate that the regulatory elements controlling the expression of the small extracellular CS/DS PGs in human endothelial cells are different.