Matrix proteoglycans: from molecular design to cellular function.
@article{Iozzo1998MatrixPF, title={Matrix proteoglycans: from molecular design to cellular function.}, author={Renato V. Iozzo}, journal={Annual review of biochemistry}, year={1998}, volume={67}, pages={ 609-52 } }
The proteoglycan superfamily now contains more than 30 full-time molecules that fulfill a variety of biological functions. Proteoglycans act as tissue organizers, influence cell growth and the maturation of specialized tissues, play a role as biological filters and modulate growth-factor activities, regulate collagen fibrillogenesis and skin tensile strength, affect tumor cell growth and invasion, and influence corneal transparency and neurite outgrowth. Additional roles, derived from studies…
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References
SHOWING 1-10 OF 535 REFERENCES
The family of the small leucine-rich proteoglycans: key regulators of matrix assembly and cellular growth.
- BiologyCritical reviews in biochemistry and molecular biology
- 1997
These proteoglycans are tissue organizers, orienting and ordering collagen fibrils during ontogeny and in pathological processes such as wound healing, tissue repair, and tumor stroma formation, and three-dimensional modeling of their prototype protein core proposes a flexible, arch-shaped binding surface suitable for strong and distinctive interactions with ligand proteins.
Heparan sulfate proteoglycans of the cardiovascular system. Specific structures emerge but how is synthesis regulated?
- BiologyThe Journal of clinical investigation
- 1997
The current state of knowledge about the structure and the biosynthesis of HSPGs are outlined as well as interactions of these components with growth factors, enzymes, and protease inhibitors are described to provide a conceptual framework for elucidating the roles of H SPGs in other biologic systems.
Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation
- BiologyNature
- 1988
Chinese hamster ovary cell lines expressing human decorin from a stably transfected complementary DNA construct form a more orderly monolayer and grow to a lower saturation density than control cells lacking decorin, revealing a novel growth inhibitory mechanism which may be related to contact inhibition of cell proliferation.
Cartilage proteoglycans: Structure and potential functions
- Biology, ChemistryMicroscopy research and technique
- 1994
The largest in size and most abundant by weight is aggrecan, a proteoglycan that possesses over 100 chondroitin sulfate and keratan sulfate chains that provides cartilage with its osmotic properties, which give articular cartilage its ability to resist compressive loads.
Expression of Small Extracellular Chondroitin/Dermatan Sulfate Proteoglycans Is Differentially Regulated in Human Endothelial Cells*
- BiologyThe Journal of Biological Chemistry
- 1997
The results indicate that the regulatory elements controlling the expression of the small extracellular CS/DS PGs in human endothelial cells are different.
Extracellular matrix, supramolecular organisation and shape.
- Biology, ChemistryJournal of anatomy
- 1995
The small proteoglycans are proposed to be tissue organisers, orienting and ordering the collagen fibrils--thus shaping the tissue at a molecular and ultimately macro level.
Negative regulation of transforming growth factor-β by the proteoglycan decorin
- BiologyNature
- 1990
The ability of decorin to bind transforming growth factor-β, an autocrine factor that stimulates the growth of Chinese hamster ovary cells, is reported, suggesting that decorin may be a component of a feedback system regulating cell growth.
Perlecan: a gem of a proteoglycan.
- BiologyMatrix biology : journal of the International Society for Matrix Biology
- 1994
Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis
- BiologyCell
- 1994
Regulation of type I collagen fibril assembly by link protein and proteoglycans.
- Biology, Computer ScienceCollagen and related research
- 1984