Matrix-protein-specific regulation of Cx43 expression in cardiac myocytes subjected to mechanical load.

Abstract

To elucidate mechanisms responsible for mechanotransduction in the heart and define the effects of remodeling of the extracellular matrix, we cultured neonatal rat ventricular myocytes on native type I collagen, fibronectin, or denatured collagen and subjected them to uniaxial, pulsatile stretch. Changes in expression of the cardiac gap junction protein… (More)

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@article{Shanker2005MatrixproteinspecificRO, title={Matrix-protein-specific regulation of Cx43 expression in cardiac myocytes subjected to mechanical load.}, author={Amit J Shanker and Kiyomi N Yamada and Karen Green and K. Yamada and Jeffrey E. Saffitz}, journal={Circulation research}, year={2005}, volume={96 5}, pages={558-66} }