Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes.

  title={Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes.},
  author={Monique Gannag{\'e} and Dorothee Dormann and Randy A Albrecht and J{\"o}rn Dengjel and Tania Torossi and Patrick C. R{\"a}mer and Monica Lee and Till Strowig and Frida Arrey and Gina M Conenello and Marc Pypaert and Jens Andersen and Adolfo Garc{\'i}a-Sastre and Christian M{\"u}nz},
  journal={Cell host & microbe},
  volume={6 4},
Influenza A virus is an important human pathogen causing significant morbidity and mortality every year and threatening the human population with epidemics and pandemics. Therefore, it is important to understand the biology of this virus to develop strategies to control its pathogenicity. Here, we demonstrate that influenza A virus inhibits macroautophagy, a cellular process known to be manipulated by diverse pathogens. Influenza A virus infection causes accumulation of autophagosomes by… CONTINUE READING
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