Matrix mini-tablets based on starch/microcrystalline wax mixtures.

  title={Matrix mini-tablets based on starch/microcrystalline wax mixtures.},
  author={Caroline De Brabander and Chris Vervaet and Lucien Fiermans and Jean Paul Remon},
  journal={International journal of pharmaceutics},
  volume={199 2},
Matrix mini-tablets based on a combination of microcrystalline waxes and starch derivatives were prepared using ibuprofen as a model drug. The production of mini-tablets was preferred over the production of pellets, as up-scaling of the pelletisation process seemed problematic. Prior to tabletting, melt granulation in a hot stage screw extruder and milling were required. The in vitro drug release was varied using microcrystalline waxes with a different melting range, the slowest drug release… CONTINUE READING

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