Matrix metalloproteinases vary with airway microbiota composition and lung function in non-cystic fibrosis bronchiectasis.

@article{Taylor2015MatrixMV,
  title={Matrix metalloproteinases vary with airway microbiota composition and lung function in non-cystic fibrosis bronchiectasis.},
  author={Steven L Taylor and Geraint Berian Rogers and Alice C-H Chen and Lucy D Burr and Michael A McGuckin and David Serisier},
  journal={Annals of the American Thoracic Society},
  year={2015},
  volume={12 5},
  pages={701-7}
}
RATIONALE Despite growing evidence for the roles of airway remodeling and bacterial infection in the progression of non-cystic fibrosis bronchiectasis, relationships between collagen-degrading proteases and chronic airway infection are poorly understood. OBJECTIVES The aim of this study was to determine which matrix metalloproteinases (MMPs) are elevated in bronchiectasis, whether these MMP levels vary based on patients' dominant infective microbe, and how these levels correlate with clinical… CONTINUE READING
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