Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis.

Abstract

M atrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, which are highly activated by inflammatory signaling, including that of angiotensin II (Ang II; Figure). Activated MMPs are able to degrade col-lagen, elastin, and other extracellular molecules, 2 probably resulting in aging, hypertension, and atherosclerotic effects within the… (More)
DOI: 10.1161/HYPERTENSIONAHA.114.03618

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