Matrix metalloproteinases inhibition attenuates tobacco smoke-induced emphysema in Guinea pigs.

@article{Selman2003MatrixMI,
  title={Matrix metalloproteinases inhibition attenuates tobacco smoke-induced emphysema in Guinea pigs.},
  author={Mois{\'e}s Selman and Jos{\'e} Cisneros-Lira and Miguel Gaxiola and Remedios Ram{\'i}rez and Elizabeth M. Kudlacz and Peter G. Mitchell and Annie Pardo},
  journal={Chest},
  year={2003},
  volume={123 5},
  pages={1633-41}
}
STUDY OBJECTIVE To evaluate the effect of CP-471,474 (Pfizer Global Research and Development; Groton, CT), a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) in an experimental model of emphysema. DESIGN Randomized, double-blinded, controlled experiment. SETTING Biochemistry and morphology laboratories and animal research facility. METHODS Guinea pigs were exposed to cigarette smoke over 1 month, 2 months, and 4 months, and half of the animals received CP-471,474. Age-matched… CONTINUE READING

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Matrix metalloproteinase (MMP-9) deficiency selectively abrogates IL-13-induced phenotypes in the lung [abstract

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