Matrix metalloproteinases in the equine systemic inflammatory response: implications for equine laminitis

  title={Matrix metalloproteinases in the equine systemic inflammatory response: implications for equine laminitis},
  author={Lee Ann Fugler},

Changes in Perioperative Antimicrobial and Anti-Inflammatory Drugs Regimens for Colic Surgery in Horses: A Single Center Report

Reducing postoperative incisional infection is the main reason to administer postoperative antimicrobials (AMD) after emergency laparotomy in horses, while reducing inflammation and providing analgesia are the reasons to administer anti-inflammatory drugs (AID).

Changes in the levels of MMP-9, MMP-2, and their inhibitors in the serum of dairy cows with laminitis

Laminitis is regarded as an important underlying cause of lameness disorders, yet its specific pathogenesis remains unclear. Consistent histological changes in cows with laminitis consist in the



Matrix metalloproteinases contribute to endotoxin and interleukin‐1β induced vascular dysfunction

The acute vascular inflammatory dysfunction associated with endotoxaemia may reflect an imbalance between matrix metalloproteinases (MMPs) and their natural inhibitors (TIMPs), induced by the

Role of matrix metalloproteinases in asthma

Notably, corticosteroids downregulate MMP and enhance TIMPs, and whether specific inhibitors of MMP could reduce airway injury and facilitate orderly healing in asthma is still unknown.

Endotoxemia in horses. A review of cellular and humoral mediators involved in its pathogenesis.

  • D. D. Morris
  • Medicine, Biology
    Journal of veterinary internal medicine
  • 1991
The numerous feedback loops and intertwining cascades of mediators during endotoxemia defy simplistic methods of treatment and the optimal therapy likely involves methods to alter the generation of inflammatory mediators by mononuclear phagocytes.

High volume continuous venovenous haemofiltration (HV-CVVH) in an equine endotoxaemic shock model.

In this study, HV-CVVH with a PMMA filter did not prove to have a significant beneficial effect on the course of experimental endotoxaemia in horses, but in a more severe model, better efficacy might be obtained and testing additional filters might lead to a more suitable therapy for horses.

Plasma and urine nitric oxide concentrations in horses given below a low dose of endotoxin.

Plasma and urine NO concentrations did not increase in horses after administration of a low dose of endotoxin, despite induction of an inflammatory response, which was confirmed by increased TNF and IL-6 values characteristic alterations in clinical signs of disease, and hematologic, hemodynamic and metabolic variables.

Chemically modified tetracyclines as inhibitors of matrix metalloproteinases.

Interactions between lipopolysaccharides and blood factors on the stimulation of equine polymorphonuclear neutrophils.

Control of matrix metalloproteinase catalytic activity.

  • H. RaW. Parks
  • Biology
    Matrix biology : journal of the International Society for Matrix Biology
  • 2007

Matrix metalloproteinase inhibitors attenuate endotoxemia induced cardiac dysfunction: A potential role for MMP-9

It is demonstrated, for the first time, that LPS induced cardiac dysfunction is associated with a loss in ventricular M MP-2 activity and the release of MMP-9 from the heart, and MMP inhibitors can significantly preserve cardiac mechanical function during septic shock.