Matrix metalloproteinases in the adult brain physiology: a link between c-Fos, AP-1 and remodeling of neuronal connections?

@article{Kaczmarek2002MatrixMI,
  title={Matrix metalloproteinases in the adult brain physiology: a link between c-Fos, AP-1 and remodeling of neuronal connections?},
  author={Leszek Kaczmarek and Joanna Lapinska-Dzwonek and Sylwia Szymczak},
  journal={The EMBO journal},
  year={2002},
  volume={21 24},
  pages={6643-8}
}
Matrix metalloproteinases (MMPs), together with their endogenous inhibitors (TIMPs) form an enzymatic system that plays an important role in a variety of physiological and pathological conditions. These proteins are also expressed in the brain, especially under pathological conditions, in which glia as well as invading inflammatory cells provide the major source of the MMP activity. Surprisingly little is known about the MMP function(s) in adult neuronal physiology. This review describes… CONTINUE READING
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