Matrix metalloproteinases in respiratory diseases: from pathogenesis to potential clinical implications.

@article{Oikonomidi2009MatrixMI,
  title={Matrix metalloproteinases in respiratory diseases: from pathogenesis to potential clinical implications.},
  author={Smaragda Oikonomidi and Konstantinos Kostikas and Irene Tsilioni and Kalliopi Tanou and Konstantinos I. Gourgoulianis and Theodoros S. Kiropoulos},
  journal={Current medicinal chemistry},
  year={2009},
  volume={16 10},
  pages={
          1214-28
        }
}
Matrix metalloproteinases (MMPs) are zinc-endopeptidases responsible for degradation of the extracellular matrix (ECM) components including basement membrane collagen, interstitial collagen, fibronectin, and various proteoglycans, during normal remodeling and repair processes. The turnover and remodeling of ECM must be tightly regulated since excessive or inappropriate expression of MMPs may contribute to the pathogenesis of tissue destructive processes associated with lung inflammation and… CONTINUE READING
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