Matrix metalloproteinases in dog brains exhibiting Alzheimer-like characteristics.

  title={Matrix metalloproteinases in dog brains exhibiting Alzheimer-like characteristics.},
  author={Giselle P. Lim and Michael J. Russell and Michael J. Cullen and Zolt{\'a}n A. T{\"o}k{\'e}s},
  journal={Journal of neurochemistry},
  volume={68 4},
We have previously reported that the amount of the neuronal matrix metalloproteinase (MMP) MMP-9, capable of cleaving beta-amyloid,-40 predominantly at Leu34-Met35, is increased in a latent form in hippocampal specimens from AD patients and have suggested that the lack of activation of this enzyme may contribute to the deposition of beta-amyloid in plaques. The current study addresses whether similar matrix proteinases are detectable in amyloid-positive and -negative brain specimens of aged… CONTINUE READING
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