Matrix metalloproteinases in colorectal cancer: Is it worth talking about?

@article{WagenaarMiller2004MatrixMI,
  title={Matrix metalloproteinases in colorectal cancer: Is it worth talking about?},
  author={Rebecca A. Wagenaar-Miller and Lee D. Gorden and Lynn M Matrisian},
  journal={Cancer and Metastasis Reviews},
  year={2004},
  volume={23},
  pages={119-135}
}
Matrix metalloproteinases (MMPs), a family of extracellular matrix degrading enzymes, are expressed in various stages of colorectal cancer (CRC) and correlate with survival and prognosis. There is considerable evidence in preclinical models that MMP inhibitors (MMPIs) are effective at multiple stages of CRC tumor progression, including reducing the number of intestinal adenomas, inhibiting the growth and establishment of primary CRC tumors, and reducing metastasis to the lung and liver. However… CONTINUE READING

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