Matrix metalloproteinases in brain development and remodeling: Synaptic functions and targets

@article{Ethell2007MatrixMI,
  title={Matrix metalloproteinases in brain development and remodeling: Synaptic functions and targets},
  author={Iryna M. Ethell and Douglas Wayne Ethell},
  journal={Journal of Neuroscience Research},
  year={2007},
  volume={85}
}
Matrix metalloproteinases (MMPs) play critical roles in egg fertilization, embryonic development, wound repair, cancer, and inflammatory and neurologic diseases. This subfamily of metzincin peptidases can cleave extracellular matrix (ECM) and pericellular proteins that have profound effects on cell behavior. Among known MMP substrates are several proteins that play important roles in synaptogenesis, synaptic plasticity, and long‐term potentiation (LTP). In this Mini‐Review we discuss how MMP… 
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Expression of membrane-type (MT) 5 matrix metalloproteinase (MMP) in the mouse brain was examined. MT5-MMP was expressed in the cerebrum in embryos, but it declined after birth. In contrast,
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