Matrix metalloproteinases in arthritic disease

  title={Matrix metalloproteinases in arthritic disease},
  author={Gillian Murphy and Vera Kn{\"a}uper and Susan J. Atkinson and George Butler and William R English and Mike Hutton and Jan Stracke and Ian Clark},
  booktitle={Arthritis research},
The role of matrix metalloproteinases in the degradative events invoked in the cartilage and bone of arthritic joints has long been appreciated and attempts at the development of proteinase inhibitors as potential therapeutic agents have been made. However, the spectrum of these enzymes orchestrating connective tissue turnover and general biology is much larger than anticipated. Biochemical studies of the individual members of the matrix metalloproteinase family are now underway, ultimately… CONTINUE READING