Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism.

@article{Yin2006MatrixME,
  title={Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism.},
  author={Ke-Jie Yin and John R Cirrito and Ping Wang Yan and Xiaoyan Hu and Qingli Xiao and Xiaoou O Pan and Randall J. Bateman and Haowei Song and F. -F. Hsu and John W. Turk and Jan de Leeuw Rick Paik Schoenberg Hongquan Xu and Chung Yao Hsu and Jason C. Mills and David M Holtzman and Jin-Moo Lee},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 43},
  pages={10939-48}
}
It has been postulated that the development of amyloid plaques in Alzheimer's disease (AD) may result from an imbalance between the generation and clearance of the amyloid-beta peptide (Abeta). Although familial AD appears to be caused by Abeta overproduction, sporadic AD (the most prevalent form) may result from impairment in clearance. Recent evidence suggests that several proteases may contribute to the degradation of Abeta. Furthermore, astrocytes have recently been implicated as a… CONTINUE READING

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