Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression.

@article{Littlepage2010MatrixMC,
  title={Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression.},
  author={Laurie E Littlepage and Mark D. Sternlicht and Nathalie Rougier and Joanna J J Phillips and Eugenio Gallo and Ying Yu and K J Williams and Audrey Brenot and Jeffrey I. Gordon and Zena Werb},
  journal={Cancer research},
  year={2010},
  volume={70 6},
  pages={2224-34}
}
Prostate cancer is the leading form of cancer in men. Prostate tumors often contain neuroendocrine differentiation, which correlates with androgen-independent progression and poor prognosis. Matrix metalloproteinases (MMP), a family of enzymes that remodel the microenvironment, are associated with tumorigenesis and metastasis. To evaluate MMPs during metastatic prostatic neuroendocrine cancer development, we used transgenic mice expressing SV40 large T antigen in their prostatic neuroendocrine… CONTINUE READING