Matrix metalloproteinases and their inhibitors in connective tissue remodeling.

  title={Matrix metalloproteinases and their inhibitors in connective tissue remodeling.},
  author={Jessica Woessner},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={5 8},
  • Jessica Woessner
  • Published 1991 in
    FASEB journal : official publication of the…
Matrix metalloproteinases are an important group of zinc enzymes responsible for degradation of the extracellular matrix components such as collagen and proteoglycans in normal embryogenesis and remodeling and in many disease processes such as arthritis, cancer, periodontitis, and osteoporosis. A matrixin family is defined, comprising at least seven members that range in size from Mr 28,000 to 92,000 and are related in gene sequence to collagenase. All family members are secreted as zymogens… CONTINUE READING
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