Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc.

@article{Roberts2000MatrixMA,
  title={Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc.},
  author={Sally Roberts and Bruce Caterson and Janis Menage and Elizabeth H Evans and David C. Jaffray and Stephen M. Eisenstein},
  journal={Spine},
  year={2000},
  volume={25 23},
  pages={3005-13}
}
STUDY DESIGN A comprehensive immunohistochemical study of matrix metalloproteinase activity in discs from patients with different disc diseases. OBJECTIVES To identify individual matrix metalloproteinase enzymes that could contribute to the degeneration of the matrix of the intervertebral disc, to identify the cells that produce matrix metalloproteinases (for example, the endogenous disc cells or invading cells associated with vascularisation), and to determine if "aggrecanase" contributes to… CONTINUE READING
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