Matrix metalloproteinases -8, -9 and -12 in smokers and patients with Stage 0 COPD

Abstract

COPD is underdiagnosed and its early assessment is problematic. It has been suggested that symptomatic smokers with normal FEV1/FVC (Stage 0 COPD, GOLD criteria) can develop COPD in the future. Potential early biomarkers in COPD include the matrix metalloproteinases (MMPs). It is not yet known, whether alterations in MMP expression are associated with… (More)

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