Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.

@article{Roelle2003MatrixM2,
  title={Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.},
  author={Susanne Roelle and Robert Grosse and Achim Aigner and Hans Willi Krell and Frank Czubayko and Thomas Gudermann},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 47},
  pages={47307-18}
}
Rapid engagement of the extracellular signal-regulated kinase (ERK) cascade via the Gq/11-coupled GnRH receptor (GnRHR) is mediated by transactivation of the epidermal growth factor receptor (EGFR). Here we show that the cross-talk between GnRHR and EGFR in gonadotropic cells is accomplished via gelatinases A and B (matrix metalloproteinases (MMPs) 2 and 9), identifying gelatinases as the first distinct members of the MMP family mediating EGFR transactivation by G protein-coupled receptors… CONTINUE READING
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