Matrix metalloproteinases: pro- and anti-angiogenic activities.

  title={Matrix metalloproteinases: pro- and anti-angiogenic activities.},
  author={Shahzad Raza and Lynn A. Cornelius},
  journal={The journal of investigative dermatology. Symposium proceedings},
  volume={5 1},
Matrix metalloproteinases (MMP) are a family of structurally related proteinases most widely recognized for their ability to degrade extracellular matrix, although recent investigations have demonstrated other biologic functions for these enzymes. MMP are typically not constitutively expressed, but are regulated by: (1) cytokines, growth factors, and cell-cell and cell-matrix interactions that control gene expression; (2) activation of their proenzyme form; and (3) the presence of MMP… CONTINUE READING


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