Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice.

Abstract

Cerebral amyloid angiopathy (CAA), characterized by extracellular beta-amyloid peptide (Abeta) deposits in vessel walls, is present in the majority of cases of Alzheimer's disease and is a major cause of hemorrhagic stroke. Although the molecular pathways activated by vascular Abeta are poorly understood, extracellular matrix metalloproteinases (MMP) and… (More)
DOI: 10.1111/j.1471-4159.2009.06096.x

Topics

6 Figures and Tables

Cite this paper

@article{GarciaAlloza2009MatrixMI, title={Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice.}, author={Monica Garcia-Alloza and Claudia M. Prada and Carli R. Lattarulo and Sara J Fine and Laura Ann Borrelli and Rebecca A. Betensky and Steven A. Greenberg and Matthew P. Frosch and Brian J. Bacskai}, journal={Journal of neurochemistry}, year={2009}, volume={109 6}, pages={1636-47} }