Matrix metalloproteinase inhibition impairs adipose tissue development in mice.

  title={Matrix metalloproteinase inhibition impairs adipose tissue development in mice.},
  author={Henri Roger Lijnen and Erik Maquoi and Lars Bolvig Hansen and Berthe Van Hoef and Liesbeth Frederix and D{\'e}sir{\'e} Collen},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={22 3},
The effect of galardin, a broad-spectrum matrix metalloproteinase (MMP) inhibitor, was studied in mice kept on a high fat diet (HFD). Five-week-old male wild-type mice were fed the HFD (42% fat) for up to 12 weeks and were daily injected intraperitoneally with the inhibitor (100 mg/kg) or with vehicle. After 12 weeks of the HFD, the body weights of both groups were comparable, but the weight of the isolated subcutaneous (SC) or gonadal (GON) fat deposits was significantly lower in the inhibitor… CONTINUE READING
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