Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice.

@article{Rohde1999MatrixMI,
  title={Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice.},
  author={Luis E. Rohde and Anique Ducharme and Luis H. Arroyo and Masanori Aikawa and Galina H. Sukhova and Arturo Lopez-Anaya and Kim F McClure and Peter G. Mitchell and Peter Libby and Richard T. Lee},
  journal={Circulation},
  year={1999},
  volume={99 23},
  pages={
          3063-70
        }
}
BACKGROUND Extracellular matrix synthesis and degradation contribute to the morphological changes that occur after myocardial infarction (MI). METHODS AND RESULTS We tested the hypothesis that inhibition of matrix metalloproteinases (MMPs) attenuates left ventricular remodeling in experimental MI. Seventy-one male FVB mice that survived ligation of the left anterior coronary artery were randomized to a broad-spectrum MMP inhibitor (CP-471,474) or placebo by gavage. Echocardiographic studies… 

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