Matrix metalloproteinase inhibition attenuates atrial remodeling and vulnerability to atrial fibrillation in a canine model of heart failure.

@article{Moe2008MatrixMI,
  title={Matrix metalloproteinase inhibition attenuates atrial remodeling and vulnerability to atrial fibrillation in a canine model of heart failure.},
  author={Gordon W. Moe and Gabriel Laurent and Liia Doumanovskaia and Andrea Konig and Xudong Hu and P. Dorian},
  journal={Journal of cardiac failure},
  year={2008},
  volume={14 9},
  pages={768-76}
}
BACKGROUND Atrial structural remodeling occurs in evolving heart failure (HF) and is an important substrate for the development of atrial fibrillation (AF). The matrix metalloproteinases (MMPs) play a role in extracellular remodeling, and recent studies have demonstrated increased atrial MMP activity in HF. Whether increased MMP activity directly contributes to atrial remodeling and AF in the setting of HF remains unclear. The current study examined the effects of MMP inhibition on atrial… CONTINUE READING

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Extracellular matrix alterations in the atria: insights into the mechanisms and perpetuation of atrial fibrillation.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology • 2012
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