Matrix metalloproteinase inhibition and the prevention of heart failure.

  • R. Todd Lee
  • Published 2001 in Trends in cardiovascular medicine


Matrix metalloproteinases (MMPs) are members of a large family of enzymes that can degrade extracellular matrix as well as other molecules. MMPs participate in a broad variety of normal and pathologic states, and recent evidence implicates the MMP family as potential mediators of cardiac dilation and progression to heart failure. This evidence is based on… (More)


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