Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-alpha inhibitor.

@article{Clements1997MatrixME,
  title={Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-alpha inhibitor.},
  author={John M. Clements and Judy A. Cossins and Graham M A Wells and Dominic J. Corkill and Karl R. Helfrich and Laurence Wood and R. J. S. Pigott and G Stabler and G. A. Abou Ward and Andrew J. H. Gearing and Karen M. Miller},
  journal={Journal of neuroimmunology},
  year={1997},
  volume={74 1-2},
  pages={85-94}
}
Matrix metalloproteinases (MMPs) are a large family of Zn2+ endopeptidases that are expressed in inflammatory conditions and are capable of degrading connective tissue macromolecules. MMP-like enzymes are also involved in the processing of a variety of cell surface molecules including the pro-inflammatory cytokine TNF-alpha. MMPs and TNF-alpha have both been implicated in the pathology associated with neuro-inflammatory diseases (NIDs), particularly multiple sclerosis (MS) and its animal model… CONTINUE READING