Matrix metalloproteinase expression and production by alveolar macrophages in emphysema.

@article{Finlay1997MatrixME,
  title={Matrix metalloproteinase expression and production by alveolar macrophages in emphysema.},
  author={G A Finlay and L. R. O’Driscoll and K. J. Russell and E M D'arcy and James B. Masterson and Muiris X. FitzGerald and Clare M. O'connor},
  journal={American journal of respiratory and critical care medicine},
  year={1997},
  volume={156 1},
  pages={
          240-7
        }
}
The aim of this study was to examine the hypothesis that alveolar macrophages represent a significant source of matrix-degrading proteinases in the emphysematous lung. Macrophages from bronchoalveolar lavage fluid of 10 patients with emphysema and 10 normal volunteers were maintained in vitro for 24 h and assessed semiquantitatively for mRNA transcript levels of the matrix metalloproteinases (MMPs) gelatinases A and B, macrophage metalloelastase (MME), and interstitial collagenase. Release of… 
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Matrix metalloproteinases and tissue inhibitor of metalloproteinase-1 in sarcoidosis and IPF

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Matrix Metalloproteinase-12 and Cathepsin D Expression in Pulmonary Macrophages and Dendritic Cells of Cigarette Smoke-Exposed Mice

Results indicate that cigarette smoke increases the expression of MMP-12 and Cathepsin D in the lungs of mice, and that not only macrophages but also DCs produce M MP-12.

Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10.

It is concluded that the release of proteases and antiproteases by airway macrophages is increased in cigarette smokers, and can be regulated by exogenous IL-10.

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