Matrix metalloproteinase expression and inhibition after sciatic nerve axotomy.

  title={Matrix metalloproteinase expression and inhibition after sciatic nerve axotomy.},
  author={Heike Siebert and N Dippel and Malin Maeder and Florian Weber and Wolfgang Br{\"u}ck},
  journal={Journal of neuropathology and experimental neurology},
  volume={60 1},
Wallerian degeneration is characterized by breakdown of myelin and axons with subsequent macrophage infiltration and removal of the degenerating nerve components. Proteinases of the matrix metalloproteinase (MMP) family seem to play an important role in demyelinating processes, since some of their members have been shown to cleave myelin basic protein. In the present study we investigated the expression of MMP-2 and MMP-9 (gelatinases A and B) during myelin removal after peripheral nerve trauma… CONTINUE READING
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